Tumour Models
Cancer-on-chip platforms recapitulating the tumour microenvironment including immune cells, vasculature, and extracellular matrix for studying metastasis and immunotherapy responses.
Tumour Micromasses
We develop 3D tumour micromass models in microfluidic devices that recapitulate the spatial heterogeneity and nutrient gradients of solid tumours. These platforms allow the study of tumour growth, invasion, and drug resistance mechanisms in a controlled and reproducible microenvironment.
Glioblastoma
Our glioblastoma-on-chip platforms model the aggressive brain tumour microenvironment including the blood-brain barrier interface, enabling the study of tumour infiltration, angiogenesis, and the evaluation of therapeutic agents that must cross the BBB to reach the tumour site.
Glioblastoma — image coming soon
Melanoma
We recreate the melanoma tumour microenvironment on chip, including interactions with dermal stroma and immune cells, to study metastatic potential, immune evasion mechanisms, and to screen immunotherapy and targeted therapy compounds.
Melanoma — image coming soon
Cholangiocarcinoma
Our biliary cancer-on-chip platforms model the unique microenvironment of cholangiocarcinoma, incorporating bile duct epithelial cells, tumour organoids, and the surrounding desmoplastic stroma to study this aggressive and difficult-to-treat malignancy.
Cholangiocarcinoma — image coming soon
Related Publications
A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma
Ballerini, M., Gali, S., Tyagi, P., Catozzi, C., Raji, H. et al.
Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine
Polidoro, M.A., Ferrari, E., Soldani, C., Franceschini, B., Rosina, A. et al.
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
Cauli, E., Polidoro, M.A., Marzorati, S., Rasponi, M., Lleo, A.
GZMKhighCD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome
Tiberti, S., Catozzi, C., Croci, O., Ballerini, M., Cagnina, D. et al.
Plasma-enhanced protein patterning in a microfluidic compartmentalized platform for multi-organs-on-chip: a liver-tumor model
Ferrari, E., Ugolini, G.S., Piutti, C., Marzorati, S., Rasponi, M.
Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11
Ungaro, F., Colombo, P., Massimino, L., Ugolini, G.S., Correale, C. et al.
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