Technological Innovations
Development of advanced biosensors, microfluidic fabrication techniques, and automation tools to enable next-generation organ-on-chip systems with real-time monitoring and high-throughput capabilities.
Biosensors & Real-Time Monitoring
We develop electrochemical and optical biosensors for non-invasive, real-time monitoring of tissue function, metabolism, and barrier integrity within organ-on-chip systems. Our label-free detection methods enable continuous data acquisition without disrupting cell cultures, providing rich longitudinal datasets for drug response and disease progression studies.
Biosensors & Real-Time Monitoring — image coming soon
Related Publications
An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue
Cordiale, A., Stanco, D., Visone, R., Stadlinger, B., Pagella, P. et al.
Microfluidic device for islet conformal coating with a polyethylene glycol-based hydrogel: innovating cell immunoprotection strategies in type 1 diabetes
Vicinanza, F., Mencarini, T., Verderio, F., Gonzalez, G.C., Montuoro, H. et al.
Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Ferrari, E., Palma, C., Vesentini, S., Occhetta, P., Rasponi, M.
Microfluidic biofabrication of 3D multicellular spheroids by modulation of non-geometrical parameters
Lopa, S., Piraino, F., Talò, G., Mainardi, V.L., Bersini, S. et al.
Design and validation of a microfluidic device for blood-brain barrier monitoring and transport studies
Ugolini, G.S., Occhetta, P., Saccani, A., Re, F., Krol, S. et al.
Generating Multicompartmental 3D Biological Constructs Interfaced through Sequential Injections in Microfluidic Devices
Ugolini, G.S., Visone, R., Redaelli, A., Moretti, M., Rasponi, M.
Microfabricated Physiological Models for In Vitro Drug Screening Applications
Ugolini, G., Cruz-Moreira, D., Visone, R., Redaelli, A., Rasponi, M.
Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniques
Lopa, S., Piraino, F., Kemp, R.J., Di Caro, C., Lovati, A.B. et al.
Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterning
Occhetta, P., Sadr, N., Piraino, F., Redaelli, A., Moretti, M. et al.
Reliable magnetic reversible assembly of complex microfluidic devices: fabrication, characterization, and biological validation
Rasponi, M., Piraino, F., Sadr, N., LaganĂ , M., Redaelli, A. et al.
Microfabricated polyester conical microwells for cell culture applications
Selimović, S., Piraino, F., Bae, H., Rasponi, M., Redaelli, A. et al.
How to embed three-dimensional flexible electrodes in microfluidic devices for cell culture applications
Pavesi, A., Piraino, F., Fiore, G.B., Farino, K.M., Moretti, M. et al.
Organ-on-Chips for Studying Tissue Barriers: Standard Techniques and a Novel Method for Including Porous Membranes Within Microfluidic Devices
Ballerini, M., Jouybar, M., Mainardi, A., Rasponi, M., Ugolini, G.S.
A Reliable Reversible Bonding Method to Perfuse Microfluidic Devices
Occhetta, P., Biffi, E., Rasponi, M.
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