Respiratory System
Air-liquid interface lung-on-chip systems replicating breathing mechanics and alveolar function for infection studies, inhalation toxicology, and respiratory disease modeling.
Healthy Lung
We develop air-liquid interface lung-on-chip systems featuring alveolar epithelial and endothelial cells separated by a porous membrane under cyclic mechanical strain mimicking breathing. These platforms recapitulate gas exchange, surfactant production, and mucociliary clearance, serving as robust baselines for toxicology and drug studies.
Healthy Lung — image coming soon
Idiopathic Pulmonary Fibrosis (IPF)
Our IPF models incorporate activated fibroblasts and pro-fibrotic stimuli in the lung-on-chip to replicate the progressive scarring and stiffening of pulmonary tissue. We study the fibrotic cascade, extracellular matrix remodeling, and evaluate anti-fibrotic therapeutic candidates in a mechanically active environment.
COPD / Asthma
We model chronic obstructive pulmonary disease and asthma on chip by incorporating airway epithelial cells, smooth muscle, and inflammatory mediators. Mechanical stimulation and exposure to environmental triggers allow us to study airway remodeling, mucus hypersecretion, and bronchial hyperresponsiveness, and to test bronchodilator and anti-inflammatory drugs.
COPD / Asthma — image coming soon
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