Multi-Organ Platforms
Body-on-chip systems connecting multiple organ modules to study inter-organ communication, systemic drug effects, and pharmacokinetics for more predictive preclinical testing.
Liver / Heart
Our liver-heart multi-organ platform connects hepatic and cardiac compartments through a shared microfluidic circulation, enabling the study of drug metabolite cardiotoxicity. The liver module metabolizes compounds into active or toxic metabolites that then reach the cardiac tissue, mimicking systemic pharmacokinetics and revealing toxicity risks missed by single-organ assays.
Liver / Heart — image coming soon
Liver / Tumour
We develop liver-tumour coupled systems to study how hepatic drug metabolism affects anti-cancer drug efficacy. By connecting a metabolically active liver module with a tumour compartment, we evaluate the pharmacokinetic-pharmacodynamic relationship of chemotherapeutic agents in a more physiologically predictive setting.
Liver / Tumour — image coming soon
Related Publications
Plasma-enhanced protein patterning in a microfluidic compartmentalized platform for multi-organs-on-chip: a liver-tumor model
Ferrari, E., Ugolini, G.S., Piutti, C., Marzorati, S., Rasponi, M.
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