Liver Functions
Advanced liver-on-chip models combining hepatocytes, endothelial cells, and Kupffer cells to predict drug-induced liver injury, enabling long-term culture and metabolic profiling.
Liver-on-Chip for Drug Toxicity
Our liver-on-chip platforms integrate primary hepatocytes or iPSC-derived hepatocyte-like cells with non-parenchymal cells in a perfused microenvironment that maintains metabolic zonation and biliary function for weeks. These systems are optimized for predicting drug-induced liver injury (DILI), enabling long-term metabolic profiling and toxicity assessment under physiological flow conditions.
Liver-on-Chip for Drug Toxicity — image coming soon
Related Publications
A method to generate perfusable physiologic-like vascular channels within a liver-on-chip model
Ferrari, E., Monti, E., Cerutti, C., Visone, R., Occhetta, P. et al.
LivHeart: a Multi Organ-on-chip platform to study off-target cardiotoxicity of drugs upon liver metabolism
Ferrari, E., Visone, R., Monti, E., Torretta, E., Moretti, M. et al.
Are slaughterhouse-obtained livers suitable for use in ex vivo perfusion research?
Ruppelt, A., Pijnenburg, I., Pappers, C., Samsom, R-A., Kock, L. et al.
A new microfluidic platform for the highly reproducible preparation of non-viral gene delivery complexes
Protopapa, G., Bono, N., Visone, R., D'Alessandro, F., Rasponi, M. et al.
Normothermic Ex Vivo Liver Platform Using Porcine Slaughterhouse Livers for Disease Modeling
Krüger, M., Ruppelt, A., Kappler, B., Van Soest, E., Samsom, R.A. et al.
Plasma-enhanced protein patterning in a microfluidic compartmentalized platform for multi-organs-on-chip: a liver-tumor model
Ferrari, E., Ugolini, G.S., Piutti, C., Marzorati, S., Rasponi, M.
Experimental liver models: from cell culture techniques to microfluidic organs-on-chip
Polidoro, M.A., Ferrari, E., Marzorati, S., Lleo, A., Rasponi, M.
Development of a microfluidic platform for high-throughput screening of non-viral gene delivery vectors
Giupponi, E., Visone, R., Occhetta, P., Colombo, F., Rasponi, M. et al.
High-throughput microfluidic platform for adherent single cells non-viral gene delivery
Occhetta, P., Malloggi, C., Gazaneo, A., Redaelli, A., Candiani, G. et al.
Delivery of cellular factors to regulate bone healing
Haumer, A., Bourgine, P.E., Occhetta, P., Born, G., Tasso, R. et al.
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