Gut Microbiome
Microfluidic platforms that co-culture intestinal epithelium with complex microbial communities under physiological oxygen gradients for studying inflammatory bowel disease and host-microbe interactions.
Healthy Gut
We develop gut-on-chip systems that replicate the intestinal epithelial barrier, villus architecture, and peristaltic-like mechanical stimulation under controlled oxygen gradients. These platforms support the long-term culture of primary intestinal cells and enable the study of nutrient absorption, barrier integrity, and immune surveillance in healthy conditions.
Healthy Gut — image coming soon
Gut Microbiome
Our anaerobic-aerobic gut-on-chip platforms enable the co-culture of living microbial communities with human intestinal epithelium. By maintaining physiological oxygen gradients across the epithelial barrier, we study host-microbiome interactions, dysbiosis mechanisms, and the impact of probiotics and dietary compounds on gut health.
Gut Microbiome — image coming soon
Related Publications
Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia
Constantinescu-Bercu, A., Smith, K.E., Wong, S.Y., Ballerini, M., Nastro, A. et al.
A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma
Ballerini, M., Gali, S., Tyagi, P., Catozzi, C., Raji, H. et al.
Interested in collaborating on this topic?
Get in Touch