Brain
Organ-on-chip platforms modelling neural tissue architecture and function, from 3D brain organoid-like constructs to interconnected neuronal circuits, for studying neurodegenerative diseases, brain development, and drug screening.
3D Brain Models
We develop three-dimensional brain-on-chip platforms that recapitulate key features of brain tissue architecture, including cellular heterogeneity and spatial organisation. By integrating neurons, astrocytes, and microglia within microfluidic devices, these models enable the study of neurodegenerative processes, neuroinflammation, and the evaluation of neuroprotective compounds in a physiologically relevant context.
3D Brain Models — image coming soon
Neuronal Circuits
Our neuronal circuit-on-chip platforms use compartmentalised microfluidic architectures to guide axonal growth and establish functional synaptic connections between distinct neuronal populations. These systems allow the study of signal propagation, synaptic plasticity, and circuit-level dysfunction relevant to conditions such as Alzheimer's and Parkinson's disease.
Neuronal Circuits — image coming soon
Related Publications
A human stem cell-derived neurosensory-epithelial circuitry on-a-chip to model herpes simplex virus reactivation
Mazzara, P.G., Criscuolo, E., Rasponi, M., Massimino, L., Muggeo, S. et al.
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara, P.G., Muggeo, S., Luoni, M., Massimino, L., Zaghi, M. et al.
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses
Iannielli, A., Ugolini, G.S., Cordiglieri, C., Bido, S., Rubio, A. et al.
Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates
Marcuzzo, S., Terragni, B., Bonanno, S., Isaia, D., Cavalcante, P. et al.
Design and validation of a microfluidic device for blood-brain barrier monitoring and transport studies
Ugolini, G.S., Occhetta, P., Saccani, A., Re, F., Krol, S. et al.
A microfluidic platform for controlled biochemical stimulation of twin neuronal networks
Biffi, E., Piraino, F., Pedrocchi, A., Fiore, G.B., Ferrigno, G. et al.
Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates
Biffi, E., Menegon, A., Piraino, F., Pedrocchi, A., Fiore, G.B. et al.
Selective Biochemical Manipulation of Twin Neuronal Networks on Microelectrode Arrays
Regalia, G., Biffi, E., Rasponi, M., Pedrocchi, A.
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