Our Research

Pioneering innovations in microfluidic technologies and MiMic systems to advance biomedical research and drug discovery.

Research Topics

Our laboratory conducts cutting-edge research at the intersection of bioengineering, microfabrication, and cell biology. We develop innovative MiMic platforms that replicate human physiology for applications in drug testing, disease modeling, and personalized medicine.

Cardiac Tissue

Development of heart-on-chip systems with integrated electrical and mechanical sensors for studying cardiac physiology, drug cardiotoxicity, and disease mechanisms using human iPSC-derived cardiomyocytes in 3D microenvironments.

Heart-on-ChipCardiologyiPSC-CMs

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Articular Joints

Microfluidic platforms recreating the articular joint environment, combining cartilage, bone, and synovial tissues to study osteoarthritis, rheumatoid arthritis, and evaluate potential therapeutic interventions.

Joint-on-ChipCartilageOsteoarthritis

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Neuromuscular Circuits

Organ-on-chip models of the neuromuscular junction integrating motor neurons, skeletal muscle cells, and supporting tissues to investigate neuromuscular disorders and drug responses.

NMJ-on-ChipMotor NeuronsMuscle

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Gut Microbiome

Microfluidic platforms that co-culture intestinal epithelium with complex microbial communities under physiological oxygen gradients for studying inflammatory bowel disease and host-microbe interactions.

Gut-on-ChipMicrobiomeIBD

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Bone Marrow

Engineered bone marrow niches on chip recapitulating hematopoiesis and the marrow microenvironment to study blood cancers, drug toxicity on hematopoietic cells, and stem cell behavior.

Marrow-on-ChipHematopoiesisStem Cells

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Brain

Organ-on-chip platforms modelling neural tissue architecture and function, from 3D brain organoid-like constructs to interconnected neuronal circuits, for studying neurodegenerative diseases, brain development, and drug screening.

Brain-on-ChipNeuroscienceNeurodegeneration

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Respiratory System

Air-liquid interface lung-on-chip systems replicating breathing mechanics and alveolar function for infection studies, inhalation toxicology, and respiratory disease modeling.

Lung-on-ChipRespiratoryALI

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Liver Functions

Advanced liver-on-chip models combining hepatocytes, endothelial cells, and Kupffer cells to predict drug-induced liver injury, enabling long-term culture and metabolic profiling.

Liver-on-ChipToxicologyDILI

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Microvasculature Systems

Integrating perfusable microvascular networks into organ-on-chip microtissues to more closely approximate in vivo physiology, enabling systemic-like interactions — including immune cell trafficking and paracrine signalling — that are impossible in avascular models.

Vasculature-on-ChipMicrofabricationPerfusionImmune System

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Tumour Models

Cancer-on-chip platforms recapitulating the tumour microenvironment including immune cells, vasculature, and extracellular matrix for studying metastasis and immunotherapy responses.

Tumour-on-ChipOncologyImmunotherapy

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Multi-Organ Platforms

Body-on-chip systems connecting multiple organ modules to study inter-organ communication, systemic drug effects, and pharmacokinetics for more predictive preclinical testing.

Body-on-ChipMulti-OrganPK/PD

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Technological Innovations

Development of advanced biosensors, microfluidic fabrication techniques, and automation tools to enable next-generation organ-on-chip systems with real-time monitoring and high-throughput capabilities.

BiosensorsMicrofabricationAutomation

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Research Keywords

MicrofluidicsOrgan-on-ChipLab-on-ChipTissue EngineeringDrug DiscoveryDisease ModelingBiosensors3D Cell CultureMicrofabricationPDMSSoft LithographyiPSC TechnologyBioprintingBiomaterialsMicrophysiological SystemsOrganoidsHigh-throughput ScreeningPersonalized MedicineIn Vitro ModelsPharmaceutical Testing

Our Engineering Platforms

Discover the core technologies, fabrication methods, and state-of-the-art facilities that enable our research in organ-on-chip and microphysiological systems.

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