Publications
Discover our latest research findings and contributions to the scientific community.
2026
Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia
Constantinescu-Bercu, A., Smith, K.E., Wong, S.Y., Ballerini, M., Nastro, A., Wiggins, B.G., Pirri, D., Li, Y., Evers, J.A.M., Tsiamita, O., Dibble, M., Pericleous, C., Paschalaki, K.E., Birdsey, G.M., Bernier-Latmani, J., Petrova, T.V., Laffan, M.A., Sivapalaratnam, S., Rasponi, M., Randi, A.M.
Blood
An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue
Cordiale, A., Stanco, D., Visone, R., Stadlinger, B., Pagella, P., Rasponi, M., Mitsiadis, T.A.
Advanced Healthcare Materials, 15(1), e02080
2025
Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform
Mainardi, A., Barbero, A., Ehrbar, M., Rasponi, M., Martin, I., Occhetta, P.
Journal of Orthopaedic Translation
Intercalated Disc Abnormalities Are Linked to Arrhythmias in Inflammatory Cardiomyopathy
Peretto, G., Rizzo, S., Menegon, A., Villatore, A., Veeraraghavan, R., Vignale, D., Castoldi, V., Perani, L., Canu, T., Panzeri, M.C., Del Rosso, S., Norata, R., Rocchi, M., Della Barbera, M., Rossi, E., Cursi, M., Bergamaschi, A., Campochiaro, C., De Luca, G., Rasponi, M., Di Resta, C., Palmisano, A., Carrera, P., Muzio, L., Pedrocchi, A.L.G., Leocani, L., Lazzeroni, D., Sanvito, F., Sala, S., Dagna, L., Camici, P.G., Martino, G., Fairweather, D., Caforio, A.L.P., Basso, C., Esposito, A., Cooper, L.T. Jr., Della Bella, P.
JACC: Clinical Electrophysiology, 11(6), 1097-1110
Microfluidic device for islet conformal coating with a polyethylene glycol-based hydrogel: innovating cell immunoprotection strategies in type 1 diabetes
Vicinanza, F., Mencarini, T., Verderio, F., Gonzalez, G.C., Montuoro, H., Bozzi, S., Agarwal, A., Rasponi, M., Redaelli, A., Tomei, A.A.
Lab on a Chip, 25(23), 6335-6348
A Compartmentalized Joint-on-chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis
Palma, C., Salehi, S., Polidoro, M.A., Moretti, M., Rasponi, M., Lopa, S., Occhetta, P.
Advanced Science
An Organ-on-Chip Platform for Strain-Controlled, Tissue-Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis
Mainardi, A., Börsch, A., Occhetta, P., Ivanek, R., Ehrbar, M., Krattiger, L., Oertle, P., Loparic, M., Martin, I., Rasponi, M., Barbero, A.
Advanced Healthcare Materials, 14(23), 2501588
A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma
Ballerini, M., Gali, S., Tyagi, P., Catozzi, C., Raji, H., Nabinejad, A., Macandog, A.D.G., Cordiale, A., Slivinschi, B.I., Kugiejko, K.K., Freisa, M., Occhetta, P., Wargo, J.A., Ferrucci, P.F., Cocorocchio, E., Segata, N., Vignati, A., Morgun, A., Deleidi, M., Manzo, T., Rasponi, M., Nezi, L.
Nature Biomedical Engineering
A compartmentalized microfluidic platform to investigate immune cells cross-talk in rheumatoid arthritis
Palma, C., Aterini, B., Ferrari, E., Mangione, M., Romeo, M., Nezi, L., Lopa, S., Manzo, T., Occhetta, P., Rasponi, M.
Biofabrication, 17(1), 015008
2024
An Advanced Mechanically Active Osteoarthritis-on-Chip Model to Test Injectable Therapeutic Formulations: The SYN321 Case Study
Palma, C., Piazza, S., Visone, R., Ringom, R., Bjorklund, U., Bermejo Gomez, A., Rasponi, M., Occhetta, P.
Advanced Healthcare Materials, 13(32), 2401187
Development of a Microfluidic Vascularized Osteochondral Model as a Drug Testing Platform for Osteoarthritis
Salehi, S., Brambilla, S., Rasponi, M., Lopa, S., Moretti, M.
Advanced Healthcare Materials, 13(31), 2402350
Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis
Niro, F., Fernandes, S., Cassani, M., Apostolico, M., Oliver-De La Cruz, J., Pereira-Sousa, D., Pagliari, S., Vinarsky, V., Zdráhal, Z., Potesil, D., Pustka, V., Pompilio, G., Sommariva, E., Rovina, D., Maione, A.S., Bersanini, L., Becker, M., Rasponi, M., Forte, G.
Translational Research, 273, 58-77
In vitro models of the crosstalk between multiple myeloma and stromal cells recapitulate the mild NF-κB activation observed in vivo
Colombo, F., Guzzeloni, V., Kizilirmak, C., Brambilla, F., Garcia-Manteiga, J.M., Tascini, A.S., Moalli, F., Mercalli, F., Ponzoni, M., Mezzapelle, R., Ferrarini, M., Ferrero, E., Visone, R., Rasponi, M., Bianchi, M.E., Zambrano, S., Agresti, A.
Cell Death and Disease, 15(10), 731
In Vitro Mechanical Stimulation to Reproduce the Pathological Hallmarks of Human Cardiac Fibrosis on a Beating Chip and Predict The Efficacy of Drugs and Advanced Therapies
Visone, R., Paoletti, C., Cordiale, A., Nicoletti, L., Divieto, C., Rasponi, M., Chiono, V., Occhetta, P.
Advanced Healthcare Materials, 13(4), 2301481
Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine
Polidoro, M.A., Ferrari, E., Soldani, C., Franceschini, B., Rosina, A., Mainardi, A., D'Autilia, F., Donadon, M., Torzilli, G., Aghemo, A., Marzorati, S., Rasponi, M., Lleo, A.
Journal of Hepatology Reports, 6(1), 100910
2023
A method to generate perfusable physiologic-like vascular channels within a liver-on-chip model
Ferrari, E., Monti, E., Cerutti, C., Visone, R., Occhetta, P., Griffith, L.G., Rasponi, M.
Biomicrofluidics, 17(61), 064103
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
Cauli, E., Polidoro, M.A., Marzorati, S., Rasponi, M., Lleo, A.
Journal of Biological Engineering, 17(1), 53
Immunomodulatory biomimetic nanoparticles target articular cartilage trauma after systemic administration
Mancino, C., Pasto, A., De Rosa, E., Dolcetti, L., Rasponi, M., McCulloch, P., Taraballi, F.
Heliyon, 9(6), e16640
LivHeart: a Multi Organ-on-chip platform to study off-target cardiotoxicity of drugs upon liver metabolism
Ferrari, E., Visone, R., Monti, E., Torretta, E., Moretti, M., Occhetta, P., Rasponi, M.
Advanced Materials Technologies, 8(8), 2201435
Are slaughterhouse-obtained livers suitable for use in ex vivo perfusion research?
Ruppelt, A., Pijnenburg, I., Pappers, C., Samsom, R-A., Kock, L., Grinwis, G.C.M., Spee, B., Rasponi, M., Stijnen, M.
Journal of International Medical Research, 51(8)
A new microfluidic platform for the highly reproducible preparation of non-viral gene delivery complexes
Protopapa, G., Bono, N., Visone, R., D'Alessandro, F., Rasponi, M., Candiani, G.
Lab on a Chip, 23, 136-145
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform
Visone, R., Lozano-Juan, F., Marzorati, S., Rivolta, M.W., Pesenti, E., Redaelli, A., Sassi, R., Rasponi, M., Occhetta, P.
Toxicological Sciences, 191(1), 47-60
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022
Naik, N.N., Vadloori, B., Poosala, S., Srivastava, P., Coecke, S., Smith, A., Akhtar, A., Roper, C., Radhakrishnan, S., Bhyravbhatla, B., Damle, M., Pulla, V.K., Hackethal, J., Horland, R., Li, A.P., Pati, F., Singh, M.S., Occhetta, P., Bisht, R., Dandekar, P., Bhagavatula, K., Pajkrt, D., Johnson, M., Weber, T., Huang, J., Hysenaj, L., Mallar, B., Ramray, B., Dixit, S., Joshi, S., Kulkarni, M.
Alternatives to Laboratory Animals, 51(4), 263-288
2022
GZMKhighCD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome
Tiberti, S., Catozzi, C., Croci, O., Ballerini, M., Cagnina, D., Soriani, C., Scirgolea, C., Gong, Z., He, J., Macandog, A.D., Nabinejad, A., Nava Lauson, C.B., Quinte', A., Bertalot, G., Petz, W.L., Ravenda, S.P., Licursi, V., Paci, P., Rasponi, M., Rotta, L., Fazio, N., Ren, G., Fumagalli-Romario, U., Schaefer, M.H., Campaner, S., Lugli, E., Nezi, L., Manzo, T.
Nature Communications, 13, 6752
Functional microvascularization of human myocardium in vitro
King, O., Cruz-Moreira, D., Sayed, A., Kermani, F., Kit-Anan, W., Sunyovszki, I., Wang, B.X., Downing, B., Fourre, J., Hachim, D., Randi, A.M., Stevens, M.M., Rasponi, M., Terracciano, C.M.
Cell Reports Methods, 2(9), 100280
Normothermic Ex Vivo Liver Platform Using Porcine Slaughterhouse Livers for Disease Modeling
Krüger, M., Ruppelt, A., Kappler, B., Van Soest, E., Samsom, R.A., Grinwis, G.C.M., Geijsen, N., Helms, J.B., Stijnen, M., Kock, L.M., Rasponi, M., Kooistra, H.S., Spee, B.
Bioengineering, 9(9), 471
Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries
Haase, K., Piatti, F., Marcano, M., Shin, Y., Visone, R., Redaelli, A., Rasponi, M., Kamm, R.D.
Biomaterials, 280, 121248
A human stem cell-derived neurosensory-epithelial circuitry on-a-chip to model herpes simplex virus reactivation
Mazzara, P.G., Criscuolo, E., Rasponi, M., Massimino, L., Muggeo, S., Palma, C., Castelli, M., Clementi, M., Burioni, R., Mancini, N., Broccoli, V., Clementi, N.
Biomedicines, 10(9), 2068
Selective Cerebrospinal Fluid Hypothermia: Bioengineering Development and In Vivo Study of an Intraventricular Cooling Device (V-COOL)
Beretta, S., Versace, A., Fiore, G.B., Piola, M., Martini, B., Bigiogera, V., Coppadoro, L., Mariani, J., Tinti, L., Pirovano, S., Monza, L., Carone, D., Riva, M., Padovano, G., Galbiati, G., Santangelo, F., Rasponi, M., Padelli, F., Giachetti, I., Aquino, D., Diamanti, S., Librizzi, L., Bruzzone, M.G., De Curtis, M., Giussani, C., Sganzerla, E.P., Ferrarese, C.
Neurotherapeutics, 19(6), 1942-1950
Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies
Chawla, S., Mainardi, A., Majumder, N., Dönges, L., Kumar, B., Occhetta, P., Martin, I., Egloff, C., Ghosh, S., Bandyopadhyay, A., Barbero, A.
Cells, 11(24), 4034
Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective
Mainardi, A., Cambria, E., Occhetta, P., Martin, I., Barbero, A., Schaeren, S., Mehrkens, A., Krupkova, O.
Frontiers in Bioengineering and Biotechnology, 9, 826867
2021
Plasma-enhanced protein patterning in a microfluidic compartmentalized platform for multi-organs-on-chip: a liver-tumor model
Ferrari, E., Ugolini, G.S., Piutti, C., Marzorati, S., Rasponi, M.
Biomedical Materials, 16(4)
Current strategies of mechanical stimulation for maturation of cardiac microtissues
Carlos-Oliveira, M., Lozano-Juan, F., Occhetta, P., Visone, R., Rasponi, M.
Biophysical Reviews, 13(5), 717-727
Modeling In Vitro Osteoarthritis Phenotypes in a Vascularized Bone Model Based on a Bone-Marrow Derived Mesenchymal Cell Line and Endothelial Cells
Pirosa, A., Tankus, E.B., Mainardi, A., Occhetta, P., Dönges, L., Baum, C., Rasponi, M., Martin, I., Barbero, A.
International Journal of Molecular Sciences, 22(17), 9581
Liver-Heart on chip models for drug safety
Ferrari, E., Rasponi, M.
APL Bioengineering, 5(3), 031505
Micro-electrode channel guide (µECG) technology: An online method for continuous electrical recording in a human beating heart-on-chip
Visone, R., Ugolini, G.S., Cruz-Moreira, D., Marzorati, S., Piazza, S., Pesenti, E., Redaelli, A., Moretti, M., Occhetta, P., Rasponi, M.
Biofabrication, 13(3), 035026
Assessing the influence of perfusion on cardiac microtissue maturation: A heart-on-chip platform embedding peristaltic pump capabilities
Cruz-Moreira, D., Visone, R., Vasques-Nóvoa, F., Barros, A.S., Leite-Moreira, A., Redaelli, A., Moretti, M., Rasponi, M.
Biotechnology and Bioengineering, 118(8), 3128-3137
Recapitulating monocyte extravasation to the synovium in an organotypic microfluidic model of the articular joint
Mondadori, C., Palombella, S., Salehi, S., Talò, G., Visone, R., Rasponi, M., Redaelli, A., Sansone, V., Moretti, M., Lopa, S.
Biofabrication, 13(4)
A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts
Mainardi, A., Carminati, F., Ugolini, G.S., Occhetta, P., Isu, G., Robles Diaz, D., Reid, G., Visone, R., Rasponi, M., Marsano, A.
Lab on a Chip, 21(21), 4177-4195
Experimental liver models: from cell culture techniques to microfluidic organs-on-chip
Polidoro, M.A., Ferrari, E., Marzorati, S., Lleo, A., Rasponi, M.
Liver International, 41(8), 1744-1761
Bioengineered culture systems to emulate and study regenerative and pharmacological processes in human dental tissues
Pagella, P., Cordiale, A., Marconi, G.D., Trubiani, O., Rasponi, M., Mitsiadis, T.A.
European Cells and Materials, 41, 502-516
Photo and Soft Lithography for Organ-on-Chip Applications
Ferrari, E., Nebuloni, F., Rasponi, M., Occhetta, P.
Methods in Molecular Biology, 2373, 1-19
Organ-on-Chips for Studying Tissue Barriers: Standard Techniques and a Novel Method for Including Porous Membranes Within Microfluidic Devices
Ballerini, M., Jouybar, M., Mainardi, A., Rasponi, M., Ugolini, G.S.
Methods in Molecular Biology, 2373, 21-38
Electromechanical Stimulation of 3D Cardiac Microtissues in a Heart-on-Chip Model
Visone, R., Occhetta, P., Rasponi, M.
Methods in Molecular Biology, 2373, 133-157
Mechanical Induction of Osteoarthritis Traits in a Cartilage-on-a-Chip Model
Mainardi, A., Occhetta, P., Rasponi, M.
Methods in Molecular Biology, 2373, 231-251
Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects
Rua, L.A., Mumme, M., Manferdini, C., Darwiche, S., Khalil, A.M., Hilpert, M., Buchner, D.A., Lisignoli, G., Occhetta, P., von Rechenberg, B., Haug, M.D., Schaefer, D.J., Jakob, M., Caplan, A.I., Martin, I., Barbero, A., Pelttari, K.
Science Translational Medicine, 13(609), eaaz4499
2020
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara, P.G., Muggeo, S., Luoni, M., Massimino, L., Zaghi, M., Tajalli-Tehrani Valverde, P., Brusco, S., Marzi, M.J., Palma, C., Colasante, G., Iannielli, A., Paulis, M., Cordiglieri, C., Giannelli, S.G., Podini, P., Gellera, C., Taroni, F., Nicassio, F., Rasponi, M., Broccoli, V.
Nature Communications, 11, 4178
Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Ferrari, E., Palma, C., Vesentini, S., Occhetta, P., Rasponi, M.
Biosensors, 10(9), 110
Microfluidic biofabrication of 3D multicellular spheroids by modulation of non-geometrical parameters
Lopa, S., Piraino, F., Talò, G., Mainardi, V.L., Bersini, S., Pierro, M., Zagra, L., Rasponi, M., Moretti, M.
Frontiers in Bioengineering and Biotechnology, 8, 366
The MICELI (MICrofluidic, ELectrical, Impedance): Prototyping a Point-of-Care Impedance Platelet Aggregometer
Roka-Moiia, Y., Bozzi, S., Ferrari, C., Mantica, G., Dimasi, A., Rasponi, M., Santoleri, A., Scavone, M., Consolo, F., Cattaneo, M., Slepian, M.J., Redaelli, A.
International Journal of Molecular Sciences, 21(4), 1174
Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model
Chawla, S., Berkelaar, M.H.M., Dasen, B., Halleux, C., Guth-Gundel, S., Kramer, I., Ghosh, S., Martin, I., Barbero, A., Occhetta, P.
Journal of Cell Science, 133(23), jcs249094
2019
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses
Iannielli, A., Ugolini, G.S., Cordiglieri, C., Bido, S., Rubio, A., Colasante, G., Valtorta, M., Cabassi, T., Rasponi, M., Broccoli, V.
Cell Reports, 29, 4646-4656
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Occhetta, P., Mainardi, A., Votta, E., Vallmajo-Martin, Q., Ehrbar, M., Martin, I., Barbero, A., Rasponi, M.
Nature Biomedical Engineering, 3, 545-557
Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates
Marcuzzo, S., Terragni, B., Bonanno, S., Isaia, D., Cavalcante, P., Cappelletti, C., Ciusani, E., Rizzo, A., Regalia, G., Yoshimura, N., Ugolini, G.S., Rasponi, M., Bechi, G., Mantegazza, M., Mantegazza, R., Bernasconi, P., Minati, L.
Neuroscience, 416, 88-99
Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11
Ungaro, F., Colombo, P., Massimino, L., Ugolini, G.S., Correale, C., Rasponi, M., Garlatti, V., Rubbino, F., Tacconi, C., Spaggiari, P., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S., D'Alessio, S.
International Journal of Cancer, 145(7), 1913-1920
A Simple Vacuum‐Based Microfluidic Technique to Establish High‐Throughput Organs‐On‐Chip and 3D Cell Cultures at the Microscale
Visone, R., Ugolini, G.S., Vinarsky, V., Penati, M., Redaelli, A., Forte, G., Rasponi, M.
Advanced Materials Technologies, 4(1), 1800319
Challenges Toward the Identification of Predictive Markers for Human Mesenchymal Stromal Cells Chondrogenic Potential
Stüdle, C., Occhetta, P., Geier, F., Mehrkens, A., Barbero, A., Martin, I.
Stem Cells Translational Medicine, 8(2), 194-204
2018
A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues
Visone, R., Talò, G., Occhetta, P., Cruz-Moreira, D., Lopa, S., Pappalardo, O.A., Moretti, M., Rasponi, M.
APL Bioengineering, 2, 046102
Enhancing all-in-one bioreactors by combining interstitial perfusion, electrical stimulation, on-line monitoring and testing within a single chamber for cardiac constructs
Visone, R., Talò, G., Lopa, S., Rasponi, M., Moretti, M.
Scientific Reports, 8, 16944
Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis
Occhetta, P., Pigeot, S., Rasponi, M., Dasen, B., Mehrkens, A., Ullrich, T., Kramer, I., Guth-Gundel, S., Barbero, A., Martin, I.
PNAS, 115(18), 4625-4630
Design and validation of a microfluidic device for blood-brain barrier monitoring and transport studies
Ugolini, G.S., Occhetta, P., Saccani, A., Re, F., Krol, S., Rasponi, M., Redaelli, A.
Journal of Micromechanics and Microengineering, 28, 044001
A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation
Occhetta, P., Isu, G., Lemme, M., Conficconi, C., Oertle, P., Raz, C., Visone, R., Cerino, G., Plodinec, M., Rasponi, M., Marsano, A.
Integrative Biology, 10, 174-183
Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation - Initial validation versus the standardized hemodynamic shearing device
Dimasi, A., Roka-Moiia, Y., Consolo, F., Rasponi, M., Fiore, G.B., Slepian, M.J., Redaelli, A.
Biomicrofluidics, 12(4), 042208
Generation of functional cardiac microtissues in a beating heart-on-a-chip
Ugolini, G.S., Visone, R., Cruz-Moreira, D., Mainardi, A., Rasponi, M.
Methods in Cell Biology, 146, 69-84
Delivery of cellular factors to regulate bone healing
Haumer, A., Bourgine, P.E., Occhetta, P., Born, G., Tasso, R., Martin, I.
Advanced Drug Delivery Reviews, 129, 285-294
2017
Generating Multicompartmental 3D Biological Constructs Interfaced through Sequential Injections in Microfluidic Devices
Ugolini, G.S., Visone, R., Redaelli, A., Moretti, M., Rasponi, M.
Advanced Healthcare Materials, 6, 1601170
Development of a microfluidic platform for high-throughput screening of non-viral gene delivery vectors
Giupponi, E., Visone, R., Occhetta, P., Colombo, F., Rasponi, M., Candiani, G.
Biotechnology and Bioengineering, 115(3), 775-784
Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms
Ugolini, G.S., Visone, R., Cruz-Moreira, D., Redaelli, A., Rasponi, M.
Future Science OA, 3, FSO191
Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices
Dimasi, A., Rasponi, M., Consolo, F., Fiore, G.B., Bluestein, D., Slepian, M.J., Redaelli, A.
Medical Engineering and Physics, 48, 31-38
Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro
Ugolini, G.S., Pavesi, A., Rasponi, M., Fiore, G.B., Kamm, R., Soncini, M.
Elife, 6, e22847
High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells
Occhetta, P., Visone, R., Rasponi, M.
Methods in Molecular Biology, 1612, 303-323
2016
Microfabricated Physiological Models for In Vitro Drug Screening Applications
Ugolini, G., Cruz-Moreira, D., Visone, R., Redaelli, A., Rasponi, M.
Micromachines, 7(12), 233
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
Zhang, Y.S., Arneri, A., Bersini, S., Shin, S.R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell'Erba, V., Bishop, C., Shupe, T., Demarchi, D., Moretti, M., Rasponi, M., Dokmeci, M.R., Atala, A., Khademhosseini, A.
Biomaterials, 110, 45-59
Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering
Visone, R., Gilardi, M., Marsano, A., Rasponi, M., Bersini, S., Moretti, M.
Molecules, 21, 1128
Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells
Gowran, A., Rasponi, M., Visone, R., Nigro, P., Perrucci, G.L., Righetti, S., Zanobini, M., Pompilio, G.
Stem Cells International, 2016, 4287158
Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devices
Consolo, F., Dimasi, A., Rasponi, M., Valerio, L., Pappalardo, F., Bluestein, D., Slepian, M.J., Fiore, G.B., Redaelli, A.
Journal of Artificial Organs, 39, 184-193
Stoichiometric control of live cell mixing to enable fluidically-encoded co-culture models in perfused microbioreactor arrays
Occhetta, P., Glass, N., Otte, E., Rasponi, M., Cooper-White, J.J.
Integrative Biology, 8, 194-204
Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., Rasponi, M.
Lab on a Chip, 16, 599-610
Design of a microfluidic strategy for trapping and screening single cells
Occhetta, P., Licini, M., Redaelli, A., Rasponi, M.
Medical Engineering and Physics, 38, 33-40
On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain
Ugolini, G.S., Rasponi, M., Pavesi, A., Santoro, R., Kamm, R., Fiore, G.B., Pesce, M., Soncini, M.
Biotechnology and Bioengineering, 113, 859-869
Gelatin hydrogels via thiol-ene chemistry
Russo, L., Sgambato, A., Visone, R., Occhetta, P., Moretti, M., Rasponi, M., Nicotra, F., Cipolla, L.
Monatshefte fur Chemie, 147, 587-592
Learn, simplify and implement: developmental re-engineering strategies for cartilage repair
Occhetta, P., Stüdle, C., Barbero, A., Martin, I.
Swiss Medical Weekly, 146, w14346
2015
Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation
Dimasi, A., Rasponi, M., Sheriff, J., Chiu, W-C., Bluestein, D., Tran, P.L., Slepian, M.J., Redaelli, A.
Biomedical Microdevices, 17, 117
Lab-on-Chip for testing myelotoxic effect of drugs and chemicals
Rasponi, M., Gazaneo, A., Bonomi, A., Ghiglietti, A., Occhetta, P., Fiore, G.B., Pessina, A., Redaelli, A.
Microfluidics and Nanofluidics, 19, 935-940
Short-term effects of microstructured surfaces: role in cell differentiation toward a contractile phenotype
Boccafoschi, F., Rasponi, M., Ramella, M., Ferreira, A.M., Vesentini, S., Cannas, M.
Journal of Applied Biomaterials and Functional Materials, 13(2), E92-E99
Controlled electromechanical cell stimulation on-a-chip
Pavesi, A., Adriani, G., Rasponi, M., Zervantonakis, I.K., Fiore, G.B., Kamm, R.D.
Scientific Reports, 5, 11800
High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes
Occhetta, P., Centola, M., Tonnarelli, B., Redaelli, A., Martin, I., Rasponi, M.
Scientific Reports, 5, 10288
Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniques
Lopa, S., Piraino, F., Kemp, R.J., Di Caro, C., Lovati, A.B., Di Giancamillo, A., Moroni, L., Peretti, G.M., Rasponi, M., Moretti, M.
Biotechnology and Bioengineering, 112, 1457-1471
High-throughput microfluidic platform for adherent single cells non-viral gene delivery
Occhetta, P., Malloggi, C., Gazaneo, A., Redaelli, A., Candiani, G., Rasponi, M.
RSC Advances, 5, 5087-5095
VA-086 methacrylate gelatine photopolymerizable hydrogels: A parametric study for highly biocompatible 3D cell embedding
Occhetta, P., Visone, R., Russo, L., Cipolla, L., Moretti, M., Rasponi, M.
Journals of Biomedical Materials Research Part A, 103, 2109-2117
Selective Biochemical Manipulation of Twin Neuronal Networks on Microelectrode Arrays
Regalia, G., Biffi, E., Rasponi, M., Pedrocchi, A.
Neuromethods, 103, 217-230
A Reliable Reversible Bonding Method to Perfuse Microfluidic Devices
Occhetta, P., Biffi, E., Rasponi, M.
Neuromethods, 103, 25-38
2013
Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterning
Occhetta, P., Sadr, N., Piraino, F., Redaelli, A., Moretti, M., Rasponi, M.
Biofabrication, 5, 35002
2012
Numerical and experimental characterization of a novel modular passive micromixer
Pennella, F., Rossi, M., Ripandelli, S., Rasponi, M., Mastrangelo, F., Deriu, M.A., Ridolfi, L., Kähler, C.J., Morbiducci, U.
Biomedical Microdevices, 14, 849-862
A microfluidic platform for controlled biochemical stimulation of twin neuronal networks
Biffi, E., Piraino, F., Pedrocchi, A., Fiore, G.B., Ferrigno, G., Redaelli, A., Menegon, A., Rasponi, M.
Biomicrofluidics, 6, 24106
Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates
Biffi, E., Menegon, A., Piraino, F., Pedrocchi, A., Fiore, G.B., Rasponi, M.
Biotechnology and Bioengineering, 109, 166-175
Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels
Piraino, F., Camci-Unal, G., Hancock, M.J., Rasponi, M., Khademhosseini, A.
Lab on a Chip, 12, 659-661
2011
Reliable magnetic reversible assembly of complex microfluidic devices: fabrication, characterization, and biological validation
Rasponi, M., Piraino, F., Sadr, N., Laganà, M., Redaelli, A., Moretti, M.
Microfluidics and Nanofluidics, 10, 1097-1107
Anisotropic material synthesis by capillary flow in a fluid stripe
Hancock, M.J., Piraino, F., Camci-Unal, G., Rasponi, M., Khademhosseini, A.
Biomaterials, 32(27), 6493-6504
Microfabricated polyester conical microwells for cell culture applications
Selimović, S., Piraino, F., Bae, H., Rasponi, M., Redaelli, A., Khademhosseini, A.
Lab on a Chip, 11(14), 2325-2332
How to embed three-dimensional flexible electrodes in microfluidic devices for cell culture applications
Pavesi, A., Piraino, F., Fiore, G.B., Farino, K.M., Moretti, M., Rasponi, M.
Lab on a Chip, 11, 1593
Realization and efficiency evaluation of a micro-photocatalytic cell prototype for real-time blood oxygenation
Rasponi, M., Ullah, T., Gilbert, R.J., Fiore, G.B., Thorsen, T.A.
Medical Engineering and Physics, 33, 887-892